The emperor's new clothes: prospective observational evaluation of the association between initial vancomycin exposure and failure rates among adult hospitalized …
Background Vancomycin is the most commonly administered antibiotic in hospitalized
patients, but optimal exposure targets remain controversial. To clarify the therapeutic exposure …
patients, but optimal exposure targets remain controversial. To clarify the therapeutic exposure …
From natural disaster to pandemic: A health-system pharmacy rises to the challenge
AD Zuckerman, PC Patel, M Sullivan… - American Journal of …, 2020 - academic.oup.com
Purpose This report describes a health-system pharmacy’s response to a natural disaster
while staff members simultaneously prepared for the coronavirus disease 2019 (COVID-19) …
while staff members simultaneously prepared for the coronavirus disease 2019 (COVID-19) …
Unlocking Applications of Cell-Free Biotechnology through Enhanced Shelf Life and Productivity of E. coli Extracts
…, WY Kao, LC Williams, CM Hight, P Patel… - ACS Synthetic …, 2020 - ACS Publications
Cell-free protein synthesis (CFPS) is a platform biotechnology that enables a breadth of
applications. However, field applications remain limited due to the poor shelf-stability of aqueous …
applications. However, field applications remain limited due to the poor shelf-stability of aqueous …
COVID-19 treatments: then and now
SS Mustafa, RA Stern, PC Patel, DK Chu - The Journal of Allergy and …, 2023 - Elsevier
The coronavirus disease 2019 (COVID-19) pandemic has evolved over the past 3+ years,
and strategies to prevent illness and treat infection have changed over time. As COVID-19 …
and strategies to prevent illness and treat infection have changed over time. As COVID-19 …
Therapeutic drug monitoring of piperacillin and tazobactam by RP-HPLC of residual blood specimens
Background Sepsis is a common diagnosis in critical care with inpatient mortality rates up to
50%. Sepsis care is organized around source control, antibiotics, and supportive care. Drug …
50%. Sepsis care is organized around source control, antibiotics, and supportive care. Drug …
Lenacapavir (Sunlenca®) for the treatment of HIV-1
STRUCTURE: Lenacapavir (previously GS-6207, brand name Sunlenca®) is a small
molecule that selectively targets the HIV-1 capsid protein (CA, p24), which is a structural …
molecule that selectively targets the HIV-1 capsid protein (CA, p24), which is a structural …
External Validation and Comparison of Clostridioides difficile Severity Scoring Systems
Background Many models have been developed to predict severe outcomes from Clostridioides
difficile infection (CDI). These models are usually developed at a single institution and …
difficile infection (CDI). These models are usually developed at a single institution and …
Population pharmacokinetics and target attainment analyses to identify a rational empirical dosing strategy for cefepime in critically ill patients
Objectives We aimed to identify rational empirical dosing strategies for cefepime treatment in
critically ill patients by utilizing population pharmacokinetics and target attainment analysis. …
critically ill patients by utilizing population pharmacokinetics and target attainment analysis. …
Commonly used fluoroquinolones cross-react with urine drug screens for opiates, buprenorphine, and amphetamines
Objectives Fluoroquinolone antibiotics are commonly used in the treatment of infections and
have previously been confirmed to cross-react with previous generations of opiates …
have previously been confirmed to cross-react with previous generations of opiates …
Evaluation of Empirical Dosing Regimens for Meropenem in Intensive Care Unit Patients Using Population Pharmacokinetic Modeling and Target Attainment Analysis
In the present study, population pharmacokinetic (PK) analysis was performed based on
meropenem data from a prospective study conducted in 114 critically ill patients with a wide …
meropenem data from a prospective study conducted in 114 critically ill patients with a wide …