▪ Abstract DNA mismatch repair (MMR) guards the integrity of the genome in virtually all cells.
It contributes about 1000-fold to the overall fidelity of replication and targets mispaired …

DNA mismatch repair (MMR) proteins are ubiquitous players in a diverse array of important
cellular functions. In its role in post-replication repair, MMR safeguards the genome …

… Msh2-deficient mice exposed to a polycyclic aromatic hydrocarbon, benzo[a]pyrene (B[a]P)
exhibit increased susceptibility to lymphomagenesis though levels of B[a]P adducts are not …

MicroRNAs (miRNAs) are small non-coding RNAs of ∼ 22 nucleotides that are involved in
negative regulation of mRNA at the post-transcriptional level. Previously, we developed …

INTRODUCTION The characterization of the full spectrum of genetic variation is critical to
understanding human health and disease. Recent technological advances have made it …

… In contrast, the estimated historical incidence of carbamazepine-induced SJS–TEN (0.23%)
would translate into approximately 10 cases among study subjects (P<0.001). …

Nucleosome remodelers of the DDM1/Lsh family are required for DNA methylation of
transposable elements, but the reason for this is unknown. How DDM1 interacts with other …

… 3a); the percentages of GFP + cardiomyocytes were 82.8 ± 1.5% in sham-operated mice,
67.5 ± 2.0% in myocardial infarction border areas (P < … Patrick CH Hsieh … Patrick CH Hsieh …

Strategies for cardiac repair include injection of cells, but these approaches have been
hampered by poor cell engraftment, survival, and differentiation. To address these shortcomings …

DNA mismatch repair is critical for increasing replication fidelity in organisms ranging from
bacteria to humans. MutS protein, a member of the ABC ATPase superfamily, recognizes …