Background Long-term complications of critical illness include intensive care unit (ICU)-acquired
weakness and neuropsychiatric disease. Immobilisation secondary to sedation might …

Background & Aims: Constipation is a common disorder, and current treatments are
generally unsatisfactory. Biofeedback might help patients with constipation and dyssynergic …

Despite their motivational appeal to learners, innovative and technologically advanced
computer simulation games targeting native English speakers frequently remain beyond the …

Objective: Physical and occupational therapy are possible immediately after intubation in
mechanically ventilated medical intensive care unit patients. The objective of this study was to …

We empirically investigated recent proposed changes to the posttraumatic stress disorder (PTSD)
diagnosis for DSM-5 using a non-clinical sample. A web survey was administered to …

Presenilin mutations result in exaggerated endoplasmic reticulum (ER) calcium release in
cellular and animal models of Alzheimer's disease (AD). In this study, we examined whether …

Accumulating evidence suggests that neurons prone to degeneration in Alzheimer's Disease
(AD) exhibit evidence of re-entry into an aberrant mitotic cell cycle. Our laboratory recently …

Deficits in synaptic function, particularly through NMDA receptors (NMDARs), are linked to
late-stage cognitive impairments in Alzheimer's disease (AD). At earlier disease stages, …

BACKGROUND: Pathophysiological characteristics differ between slow transit constipation (STC)
and dyssynergic defecation, but whether psychological profiles and quality of life (QOL…

Alzheimer’s disease (AD) is a devastating neurodegenerative condition with no known cure.
While current therapies target late-stage amyloid formation and cholinergic tone, to date, …