Respiratory risks from household air pollution in low and middle income countries
A third of the world's population uses solid fuel derived from plant material (biomass) or coal
for cooking, heating, or lighting. These fuels are smoky, often used in an open fire or simple …
for cooking, heating, or lighting. These fuels are smoky, often used in an open fire or simple …
The “one-bead-one-compound” combinatorial library method
KS Lam, M Lebl, V Krchňák - Chemical reviews, 1997 - ACS Publications
… Lam 4 further recognized that because each bead encountered only one amino acid at each
coupling … Its structure was determined from MS experiments and the activity (K i = 4 μM) was …
coupling … Its structure was determined from MS experiments and the activity (K i = 4 μM) was …
Tumors of the heart. A 20-year experience with a review of 12,485 consecutive autopsies.
KY Lam, P Dickens, AC Chan - Archives of pathology & laboratory …, 1993 - europepmc.org
Cardiac involvement by primary and secondary tumors is one of the least investigated
subjects in oncology. Seven cases of primary and 154 cases of secondary cardiac tumors from …
subjects in oncology. Seven cases of primary and 154 cases of secondary cardiac tumors from …
Rational design of cationic lipids for siRNA delivery
We adopted a rational approach to design cationic lipids for use in formulations to deliver
small interfering RNA (siRNA). Starting with the ionizable cationic lipid 1,2-dilinoleyloxy-3-…
small interfering RNA (siRNA). Starting with the ionizable cationic lipid 1,2-dilinoleyloxy-3-…
Obstructive sleep apnea is independently associated with insulin resistance
MSM Ip, B Lam, MMT Ng, WK Lam… - American journal of …, 2002 - atsjournals.org
Epidemiological studies have implicated obstructive sleep apnea (OSA) as an independent
comorbid factor in cardiovascular and cerebrovascular diseases. It is postulated that …
comorbid factor in cardiovascular and cerebrovascular diseases. It is postulated that …
A new type of synthetic peptide library for identifying ligand-binding activity
KS Lam, SE Salmon, EM Hersh, VJ Hruby… - Nature, 1991 - nature.com
OUR aim was to improve techniques for drug development by facilitating the identification of
small molecules that bind with high affinity to acceptor molecules (for example, cell-surface …
small molecules that bind with high affinity to acceptor molecules (for example, cell-surface …
Prevalence, awareness, treatment, and control of hypertension among United States adults 1999–2004
Detection of hypertension and blood pressure control are critically important for reducing
the risk of heart attacks and strokes. We analyzed the trends in the prevalence, awareness, …
the risk of heart attacks and strokes. We analyzed the trends in the prevalence, awareness, …
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V (D) J rearrangement
Y Shinkai, KP Lam, EM Oltz, V Stewart, M Mendelsohn… - Cell, 1992 - cell.com
We have generated mice that carry a germline mutation in which a large portion of the RAG-2
coding region is deleted. Homozygous mutants are viable but fail to produce mature B or T …
coding region is deleted. Homozygous mutants are viable but fail to produce mature B or T …
RNAi-mediated gene silencing in non-human primates
…, LB Jeffs, M John, AD Judge, K Lam, K McClintock… - Nature, 2006 - nature.com
The opportunity to harness the RNA interference (RNAi) pathway to silence disease-causing
genes holds great promise for the development of therapeutics directed against targets that …
genes holds great promise for the development of therapeutics directed against targets that …
[HTML][HTML] In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
Gene targeting experiments have demonstrated that the expression of immunoglobulin heavy
chain in the pre-B cell receptor (pBCR) and of heavy and light chains in the B cell antigen …
chain in the pre-B cell receptor (pBCR) and of heavy and light chains in the B cell antigen …