Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell–mediated …
CD20 is an important target for the treatment of B-cell malignancies, including non-Hodgkin
lymphoma as well as autoimmune disorders. B-cell depletion therapy using monoclonal …
lymphoma as well as autoimmune disorders. B-cell depletion therapy using monoclonal …
Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies
…, M Thomas, W Scheuer, C Klein - Proceedings of the …, 2011 - National Acad Sciences
We describe a generic approach to assemble correctly two heavy and two light chains, derived
from two existing antibodies, to form human bivalent bispecific IgG antibodies without use …
from two existing antibodies, to form human bivalent bispecific IgG antibodies without use …
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
…, Z Filipovic, N Kong, U Kammlott, C Lukacs, C Klein… - Science, 2004 - science.org
MDM2 binds the p53 tumor suppressor protein with high affinity and negatively modulates its
transcriptional activity and stability. Overexpression of MDM2, found in many human tumors…
transcriptional activity and stability. Overexpression of MDM2, found in many human tumors…
Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker
…, A Zoephel, G Bader, M Sanderson, C Klein… - … of Pharmacology and …, 2012 - ASPET
Deregulation of the ErbB (proto-oncogene B of the avian erythroblastosis virus AEV-H strain)
receptor network is well recognized as an oncogenic driver in epithelial cancers. Several …
receptor network is well recognized as an oncogenic driver in epithelial cancers. Several …
Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53
R Stoll, C Renner, S Hansen, S Palme, C Klein… - Biochemistry, 2001 - ACS Publications
The oncoprotein MDM2 inhibits the tumor suppressor protein p53 by binding to the p53
transactivation domain. The p53 gene is inactivated in many human tumors either by mutations …
transactivation domain. The p53 gene is inactivated in many human tumors either by mutations …
[BOOK][B] Pressure and temperature sensitive paints
The first edition of the book “Pressure and Temperature Sensitive Paints” published by
Springer in 2005 summarizes the early development of pressure-and temperature-sensitive …
Springer in 2005 summarizes the early development of pressure-and temperature-sensitive …
The influence of firm size on the ESG score: Corporate sustainability ratings under review
The concept of sustainable and responsible (SR) investments expresses that every investment
should be based on the SR investor’s code of ethics. To a large extent the allocation of …
should be based on the SR investor’s code of ethics. To a large extent the allocation of …
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade
…, M Wiese, D Lardinois, PC Ho, C Klein… - Nature medicine, 2018 - nature.com
Evidence from mouse chronic viral infection models suggests that CD8 + T cell subsets
characterized by distinct expression levels of the receptor PD-1 diverge in their state of …
characterized by distinct expression levels of the receptor PD-1 diverge in their state of …
Climate change impact and adaptation for wheat protein
…, BT Kassie, KC Kersebaum, C Klein… - Global change …, 2019 - Wiley Online Library
Wheat grain protein concentration is an important determinant of wheat quality for human
nutrition that is often overlooked in efforts to improve crop production. We tested and applied a …
nutrition that is often overlooked in efforts to improve crop production. We tested and applied a …
[HTML][HTML] Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling
Angiopoietin-2 (ANG-2) is a key regulator of angiogenesis that exerts context-dependent
effects on ECs. ANG-2 binds the endothelial-specific receptor tyrosine kinase 2 (TIE2) and acts …
effects on ECs. ANG-2 binds the endothelial-specific receptor tyrosine kinase 2 (TIE2) and acts …