Regulation of cancer cell metabolism

RA Cairns, IS Harris, TW Mak - Nature Reviews Cancer, 2011 - nature.com
Interest in the topic of tumour metabolism has waxed and waned over the past century of
cancer research. The early observations of Warburg and his contemporaries established that …

Photonics and optoelectronics of 2D semiconductor transition metal dichalcogenides

KF Mak, J Shan - Nature Photonics, 2016 - nature.com
Recent advances in the development of atomically thin layers of van der Waals bonded solids
have opened up new possibilities for the exploration of 2D physics as well as for materials …

Modulation of oxidative stress as an anticancer strategy

C Gorrini, IS Harris, TW Mak - Nature reviews Drug discovery, 2013 - nature.com
The regulation of oxidative stress is an important factor in both tumour development and
responses to anticancer therapies. Many signalling pathways that are linked to tumorigenesis …

A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for …

…, SE Lipshultz, S London, R Lozano, Y Lu, J Mak… - The lancet, 2012 - thelancet.com
Background Quantification of the disease burden caused by different risks informs
prevention by providing an account of health loss different to that provided by a disease-by-disease …

Direct evidence for neutrino flavor transformation from neutral-current interactions in the Sudbury Neutrino Observatory

…, W Locke, S Luoma, J Lyon, S Majerus, HB Mak… - Physical review …, 2002 - APS
Observations of neutral-current ν interactions on deuterium in the Sudbury Neutrino
Observatory are reported. Using the neutral current (NC), elastic scattering, and charged current …

Atomically Thin : A New Direct-Gap Semiconductor

KF Mak, C Lee, J Hone, J Shan, TF Heinz - Physical review letters, 2010 - APS
The electronic properties of ultrathin crystals of molybdenum disulfide consisting of N= 1, 2,…,
6 S-Mo-S monolayers have been investigated by optical spectroscopy. Through …

DrugBank 3.0: a comprehensive resource for 'omics' research on drugs

…, S Ly, A Frolkis, A Pon, K Banco, C Mak… - Nucleic acids …, 2010 - academic.oup.com
DrugBank ( http://www.drugbank.ca ) is a richly annotated database of drug and drug target
information. It contains extensive data on the nomenclature, ontology, chemistry, structure, …

MicroRNA expression profiles classify human cancers

…, J Lamb, D Peck, A Sweet-Cordero, BL Ebert, RH Mak… - nature, 2005 - nature.com
Recent work has revealed the existence of a class of small non-coding RNA species, known
as microRNAs (miRNAs), which have critical functions across various biological processes …

Control of valley polarization in monolayer MoS2 by optical helicity

KF Mak, K He, J Shan, TF Heinz - Nature nanotechnology, 2012 - nature.com
Electronic and spintronic devices rely on the fact that free charge carriers in solids carry
electric charge and spin. There are, however, other properties of charge carriers that might be …

Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4

…, KP Lee, CB Thompson, H Griesser, TW Mak - Science, 1995 - science.org
The role of the cell-surface molecule CTLA-4 in the regulation of T cell activation has been
controversial. Here, lymph nodes and spleens of CTLA-4-deficient mice accumulated T cell …